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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

KarnOTAL JORDER/S MALBROOM JJIRON/ARELLaggressive slight nausea from consuming a high-fat meal Ex. sildenafilMinor: minor but not immediate

C.

Here are the key drug-food Interactions:

1. : Grapefruit can increase the levels of tadalafil by inhibiting the metabolism of tadalafil.
2. : Though this interaction does not appear to alter tadalafil levels in your blood, it can affect how contending you think it is about consuming the medication.
3. : While you can take a heavy meal, enjoying a light meal, or a light dinner with a high-fat meal does not increase the onset of action.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

• Headache
• Indigestion
• Heartburn
• Upset stomach
• Gas
• Nausea
• Flushing

More severe side effects include:

• Painful erections or erections that last longer than 4 hours
• Sudden loss of vision
• Sudden loss of hearing
• Ringing in the ears
• Chest pain
• Shortness of breath
• Painful urination
• Increased urination frequency
• Fainting
• Dizziness
• Skin rash
• Hives
• Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read more about Cialis's effects on erectile dysfunction.10 readWriteWrite writeShare Share Pin Share Share Share Pin Share Share

By sharing, youll reduce the risk of spreading the spread of the virus that causes erectile dysfunction. Remember, defer to your doctor or pharmacist if you have any questions or concerns about your health.

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Cialis can significantly impact your libido. Lest you think you are experiencing, here are a few common examples:

• Increased volume of semen
• Jaundice
• Sexual problems in women

Here are a few other examples of these effects:

Viagra can cause a potentially serious side effect when taken at the same time as Cialis.This can include:

• Pain in the arms or legs

Ergot alkaloids, such as ergot- derivative ergotamine and ergotamine derivatives, also can cause a potentially serious side effect when taken at the same time as Cialis.

• Stomach pain
• Back pain

Here are a few other side effects that can be reported with Cialis use:

Alpha-blockers can cause a potentially serious side effect when taken at the same time as Cialis.

Erectile dysfunction medication can cause a potentially serious side effect when taken at the same time as Cialis.

• Tachycardia
• Muscle pain

Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.

Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.

You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.

Read the label of any medication uses and contents and whether it is taken by someone else and if so it can worsen your symptoms of erectile dysfunction and BPH (benign prostatic hyperplasia). Tadalafil is not recommended for use in children as safety and effectiveness have not been established. If you suffer from other diseases, infections or medication, you should not take this medicine. Tadalafil is not recommended for use in pregnant or breastfeeding women. Consult your doctor before taking Tadalafil if you are pregnant or breastfeeding. Avoid drinking alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectivenessmediated with health care professionals and government agencies have not been independently confirmed. If you are allergic to Tadalafil or any of the other ingredients of this medicine (sildenafil, Viagra, Dapox, Cialis etc.), you should not take this medicine. If you are planning to exercise, you should not take this medicine. Tadalafil can make you dizzy, so do not drive or operate machinery until you know how this medicine affects you.

This medicine is not indicated for use in women. Tadalafil is not recommended for use in children. Before taking Tadalafil, tell your doctor if you are pregnant, planning to have a children, or are breastfeeding. Tadalafil can pass into your breast milk and could harm your milk-making system. This medicine should not be used in children if you take it by someone else. Contains lactose.

This medicine is not recommended for use in pregnant or breastfeeding women. Tadalafil is not recommended for use before taking any type of medicine, including medicine. This medicine is not indicated for use in pregnant or breastfeeding women.

Ask your doctor before using any prescription and non-prescription medicine.Take Tadalafil for as long as your doctor has prescribed it for you. In some cases, you may experience side effects such as headache, back pain, muscle pain, pain in legs and arms, nasal congestion, indigestion, and face reddening.

Ask your doctor before using any prescribed and non-prescription medicine as your symptoms may be similar to those of your own body. Some medicines may not be safe for you to use if you have diabetes, high blood pressure, heart disease, liver disease or kidney disease.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire

What is Tadalafil?

Tadalafil is the generic version of the drugsCialis, Levitra, Staxyn, and Levitra Plus.

Tadalafil is – or is standardised for – as part of a medical consultation that asks for any medications that can't be taken alongside Tadalafil.

There are a few drug classes of Tadalafil, including :

• Tadalafil HCT

• Tadalafil Generic

• Tadalafil Brand

• Tadalafil Dissolution test

How does Tadalafil work?

Tadalafil works by relaxing the blood vessels in the penis, which allows more blood to get back into the penis when you get sexually excited by an increase in blood flow in the penis.

You will only get an erection if you sexual stimulation occurs. If you still get an erection,0 no condom is needed to prevent sexual contact.

What is the active ingredient in Tadalafil?

Iodineceryt-capnocaine

Iodine-powder

Tadalafil / Cialis (Cialis, Levitra)

is used to help relax the penis muscles and blood vessels.

Iodine-Pill

Pill is the active ingredient in Cialis and Levitra.

How do I take Tadalafil?

Partners are given a single daily dose of Tadalafil HCT.

The usual dose is to take the tablet about one hour before you want to have sex.

Recommended dosage for erectile dysfunction is 10mg.

Recommended dosage for urinary dysfunction is 20mg.